Virology and Microbiology

Objective: This study is intended to explore the risk factors and drug resistance features of hospital-acquired methicillinresistant Staphylococcus aureus (MRSA) infection by investigation on hospital-acquired MRSA infectious cases.

 

Methods: The clinical data of 88 cases with hospital-acquired Staphylococcus aureus infection was collected in our hospital from July 2016 to June 2017 for hospital risk factors and drug resistance analysis; SPSS 16 software was used for statistical analysis of the data; χ2 test and Logistic regression were used for analysis.

 

Results: Logistic regression analysis was conducted on multiple variables. The kinds of antibiotics ≥3 kinds was the independent risk factor of MRSA respectively; More than 3 kinds of antibiotics were used and the infection rate was 64.86%; The OR values of the risk factor was 4.198; MRSA showed higher resistance to gentamicin, ciprofloxacin, clindamycin, erythromycin, or tetracycline and rifampicin than MSSA, the drug resistance rate was 51.43%, 65.71%, 88.57%, 80%, 77.14% and 42.86% respectively.

 

Conclusion: Hospital-acquired MRSA multidrug resistance phenomenon is more serious, more than 3 kinds of antibiotics independent risk factor for MRSA infection, clinicians should strengthen the rational use of antimicrobial drugs according to patient characteristics, and actively take hospital infection prevention and control measures to prevent the emergence of multidrug resistance MRSA.