Clayton A Dehn
Title: Early proof of concept with human viral challenge models in vaccine development
Biography
Biography: Clayton A Dehn
Abstract
The pharmaceutical industry is constantly searching for efficiencies for the development of new medicinal products. Viral vaccine development is no exception. The Human Viral Challenge Model (HVCM) is a widely accepted alternative to field studies. The standardized exposure of intentional viral inoculation of volunteers in a controlled clinical environment enriches the prevalence of infection. This also permits the study of the entire disease lifecycle from health to disease and recovery back to health. These methods reduce study population size requirements and the overall trial duration. The cumulative effect of these advantages is a risk and cost containing accelerated route to market for antiviral drugs, diagnostics and vaccines