Anti-virulence and Cell-mediated immunity

Anti-virulence is the concept of blocking virulence factors, which are produced by viruses and enable them to achieve inhibition of the host’s immune response. These factors are used to promote colonization of the host. A major group of virulence factors are proteins that can control the activation levels of GTPases. Immune response that does not involve antibodies, but rather involves the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen is known as Cell-mediated Immunity. CD4 cells provide protection against different pathogens.

  • Blocking virulence factors
  • Cytotoxic T lymphocytes
  • Immunoglobulin (Ig) proteases
  • Endotoxins and Exotoxins